Expanded Numbers of Circulating Myeloid Dendritic Cells in Patent Human Filarial Infection Reflect Lower CCR1 Expression
Identifieur interne : 005907 ( Main/Exploration ); précédent : 005906; suivant : 005908Expanded Numbers of Circulating Myeloid Dendritic Cells in Patent Human Filarial Infection Reflect Lower CCR1 Expression
Auteurs : Roshanak Tolouei Semnani [États-Unis] ; Lily Mahapatra [États-Unis] ; Benoit Dembele [Mali] ; Siaka Konate [Mali] ; Simon Metenou [États-Unis] ; Housseini Dolo [Mali] ; Michel E. Coulibaly [Mali] ; Lamine Soumaoro [Mali] ; Siaka Y. Coulibaly [Mali] ; Dramane Sanogo [Mali] ; Salif Seriba Doumbia [Mali] ; Abdallah A. Diallo [Mali] ; Sekou F. Traoré [Mali] ; Amy Klion [États-Unis] ; Thomas B. Nutman [États-Unis] ; Siddhartha Mahanty [États-Unis]Source :
- Journal of Immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2010.
Abstract
APC dysfunction has been postulated to mediate some of the parasite-specific T cell unresponsiveness seen in patent filarial infection. We have shown that live microfilariae of
Url:
DOI: 10.4049/jimmunol.1001605
PubMed: 20956349
PubMed Central: 3403815
Affiliations:
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type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Mahapatra, Lily" sort="Mahapatra, Lily" uniqKey="Mahapatra L" first="Lily" last="Mahapatra">Lily Mahapatra</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Dembele, Benoit" sort="Dembele, Benoit" uniqKey="Dembele B" first="Benoit" last="Dembele">Benoit Dembele</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Konate, Siaka" sort="Konate, Siaka" uniqKey="Konate S" first="Siaka" last="Konate">Siaka Konate</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Metenou, Simon" sort="Metenou, Simon" uniqKey="Metenou S" first="Simon" last="Metenou">Simon Metenou</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Dolo, Housseini" sort="Dolo, Housseini" uniqKey="Dolo H" first="Housseini" last="Dolo">Housseini Dolo</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Coulibaly, Michel E" sort="Coulibaly, Michel E" uniqKey="Coulibaly M" first="Michel E." last="Coulibaly">Michel E. Coulibaly</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Soumaoro, Lamine" sort="Soumaoro, Lamine" uniqKey="Soumaoro L" first="Lamine" last="Soumaoro">Lamine Soumaoro</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Coulibaly, Siaka Y" sort="Coulibaly, Siaka Y" uniqKey="Coulibaly S" first="Siaka Y." last="Coulibaly">Siaka Y. Coulibaly</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Sanogo, Dramane" sort="Sanogo, Dramane" uniqKey="Sanogo D" first="Dramane" last="Sanogo">Dramane Sanogo</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Doumbia, Salif Seriba" sort="Doumbia, Salif Seriba" uniqKey="Doumbia S" first="Salif Seriba" last="Doumbia">Salif Seriba Doumbia</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Diallo, Abdallah A" sort="Diallo, Abdallah A" uniqKey="Diallo A" first="Abdallah A." last="Diallo">Abdallah A. Diallo</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Traore, Sekou F" sort="Traore, Sekou F" uniqKey="Traore S" first="Sekou F." last="Traoré">Sekou F. Traoré</name><affiliation wicri:level="1"><nlm:aff id="A2">Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Filariasis Unit, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako</wicri:regionArea><wicri:noRegion>Bamako</wicri:noRegion></affiliation></author><author><name sortKey="Klion, Amy" sort="Klion, Amy" uniqKey="Klion A" first="Amy" last="Klion">Amy Klion</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Mahanty, Siddhartha" sort="Mahanty, Siddhartha" uniqKey="Mahanty S" first="Siddhartha" last="Mahanty">Siddhartha Mahanty</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of Immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><idno type="eISSN">1550-6606</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">APC dysfunction has been postulated to mediate some of the parasite-specific T cell unresponsiveness seen in patent filarial infection. We have shown that live microfilariae of <italic>Brugia malayi</italic> induce caspase-dependent apoptosis in human monocyte-derived dendritic cells (DCs) in vitro. This study addresses whether apoptosis observed in vitro extends to patent filarial infections in humans and is reflected in the number of circulating myeloid DCs (mDCs; CD11c<sup>−</sup>CD123<sup>lo</sup>) in peripheral blood of infected microfilaremic individuals. Utilizing flow cytometry to identify DC subpopulations (mDCs and plasmacytoid DCs [pDCs]) based on expression of CD11c and CD123, we found a significant increase in numbers of circulating mDCs (CD11c<sup>+</sup>CD123<sup>lo</sup>) in filaria-infected individuals compared with uninfected controls from the same filaria-endemic region of Mali. Total numbers of pDCs, monocytes, and lymphocytes did not differ between the two groups. To investigate potential causes of differences in mDC numbers between the two groups, we assessed chemokine receptor expression on mDCs. Our data indicate that filaria-infected individuals had a lower percentage of circulating CCR1<sup>+</sup> mDCs and a higher percentage of circulating CCR5<sup>+</sup> mDCs and pDCs. Finally, live microfilariae of <italic>B. malayi</italic> were able to downregulate cell-surface expression of CCR1 on monocyte-derived DCs and diminish their calcium flux in response to stimulation by a CCR1 ligand. These findings suggest that microfilaria are capable of altering mDC migration through downregulation of expression of some chemokine receptors and their signaling functions. These observations have major implications for regulation of immune responses to these long-lived parasites.</p></div></front></TEI><affiliations><list><country><li>Mali</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Semnani, Roshanak Tolouei" sort="Semnani, Roshanak Tolouei" uniqKey="Semnani R" first="Roshanak Tolouei" last="Semnani">Roshanak Tolouei Semnani</name></region><name sortKey="Klion, Amy" sort="Klion, Amy" uniqKey="Klion A" first="Amy" last="Klion">Amy Klion</name><name sortKey="Mahanty, Siddhartha" sort="Mahanty, Siddhartha" uniqKey="Mahanty S" first="Siddhartha" last="Mahanty">Siddhartha Mahanty</name><name sortKey="Mahapatra, Lily" sort="Mahapatra, Lily" uniqKey="Mahapatra L" first="Lily" last="Mahapatra">Lily Mahapatra</name><name sortKey="Metenou, Simon" sort="Metenou, Simon" uniqKey="Metenou S" first="Simon" last="Metenou">Simon Metenou</name><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></country><country name="Mali"><noRegion><name sortKey="Dembele, Benoit" sort="Dembele, Benoit" uniqKey="Dembele B" first="Benoit" last="Dembele">Benoit Dembele</name></noRegion><name sortKey="Coulibaly, Michel E" sort="Coulibaly, Michel E" uniqKey="Coulibaly M" first="Michel E." last="Coulibaly">Michel E. Coulibaly</name><name sortKey="Coulibaly, Siaka Y" sort="Coulibaly, Siaka Y" uniqKey="Coulibaly S" first="Siaka Y." last="Coulibaly">Siaka Y. Coulibaly</name><name sortKey="Diallo, Abdallah A" sort="Diallo, Abdallah A" uniqKey="Diallo A" first="Abdallah A." last="Diallo">Abdallah A. Diallo</name><name sortKey="Dolo, Housseini" sort="Dolo, Housseini" uniqKey="Dolo H" first="Housseini" last="Dolo">Housseini Dolo</name><name sortKey="Doumbia, Salif Seriba" sort="Doumbia, Salif Seriba" uniqKey="Doumbia S" first="Salif Seriba" last="Doumbia">Salif Seriba Doumbia</name><name sortKey="Konate, Siaka" sort="Konate, Siaka" uniqKey="Konate S" first="Siaka" last="Konate">Siaka Konate</name><name sortKey="Sanogo, Dramane" sort="Sanogo, Dramane" uniqKey="Sanogo D" first="Dramane" last="Sanogo">Dramane Sanogo</name><name sortKey="Soumaoro, Lamine" sort="Soumaoro, Lamine" uniqKey="Soumaoro L" first="Lamine" last="Soumaoro">Lamine Soumaoro</name><name sortKey="Traore, Sekou F" sort="Traore, Sekou F" uniqKey="Traore S" first="Sekou F." last="Traoré">Sekou F. Traoré</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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